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Cornell University

The Cosgrove Laboratory

Systems bioengineering analysis of signaling networks in stem cells and tissue regeneration


Full List of Publications

Pre-Prints & Accepted Manuscripts:

Pre-prints & Manuscripts Under Review:

29.Norris AM, Johnson CD, Zhou LY, Appu A, McKellar DW, Cosgrove BD, Kopinke D. “Hedgehog signaling acts as cell fate determinant during adult tissue repair.” bioRxiv 2022.08.15.504012. Link

28. Loiben AM*, Kim K-H*, Soueid-Baumgarten S*, Aguilar VM, Chin Cheong J, Kopyto R, Fraczek P, Fong EHH, Mangal R, Archer L, Cosgrove BD. (2020) “Long-term high-yield skeletal muscle stem cell expansion through staged perturbation of cytokine signaling in a soft hydrogel culture platform.” bioRxiv 2020.06.04.134056. Link


27. McKellar DW, Mantri M, Hinchman M, Parker JSL, Sethupathy P, Cosgrove BD*, De Vlaminck I.* (2022) “Spatial mapping of the total transcriptome by in situ polyadenylation.” Nat Biotechnol, in press. Link (Preprint: bioRxiv 2022.04.20.488964. Link)

See news summary in Nature Biotechnology

See news report in Cornell Chronicle

26. Lee U, Stuelsatz P, Karaz S, McKellar DW, Russeil J, Deak M, De Vlamick I, Lepper C, Deplankce B, Cosgrove BD, Feige JN. (2022) “A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle.” iScience, 25(7): 104589. Link

25. McKellar DW, Walter LD, Song LT, Mantri M, Wang MFZ, De Vlaminck I*, Cosgrove BD*. (2021) “Large-scale integration of single-cell transcriptomic data captures transitional progenitor cell states in mouse skeletal muscle regeneration.” Communications Biology 4: 1280. Link (Pre-print: bioRxiv 2020.12.01.407460 Link)

scMuscle Data Viewer Website: Link

See news report in Cornell Chronicle

24. Chovatiya G, Ghuwalewala S, Walter LD, Cosgrove BD, Tumbar T. (2020) “High resolution single cell transcriptomics reveals heterogeneity of self-renewing hair follicle stem cells.” Experimental Dermatology, 30(4): 457-471. Link

23. Gheller BJ, Blum JE, Lim EW, Handzlik MK, Fong EHH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE. (2020) “Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.” Molecular Metabolism 43: 101106. Link (Pre-print: bioRxiv 833798 Link)

22. De Micheli AJ, Swanson JB, Disser NP, Martinez LM, Walker NR, Olivier D, Cosgrove BD, Mendias CL. (2020) “A single-cell transcriptional atlas identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons.” American Journal of Physiology-Cell Physiology 319(5): C885-C894 Link (Pre-print: bioRxiv 801266 Link)

21. Gheller BJ, Blum JE, Fong EHH, Malysheva O, Cosgrove BD, Thalacker-Mercer AE. (2020) “A defined N6-methyladenosine (m6A) profile conferred by METTL3 regulates muscle stem
cell/myoblast state transitions.” Cell Death Discovery 6: 95. Link

20. Fu DJ, De Micheli AJ, Bidarimath M, Ellenson LH, Cosgrove BD, Flesken-Nikitin A, Nikitin A. (2020) “Cells expressing PAX8 are the main source of homeostatic regeneration of adult
endometrial epithelium and give rise to serous endometrial carcinoma.” Disease Models & Mechanisms 13: dmm047035. Link (Pre-print: bioRxiv 853994 Link)

19. De Micheli AJ, Spector JA, Elemento O, Cosgrove BD. (2020) “A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations.” Skeletal Muscle 10: 19. Link (bioRxiv 91473. Link)

18. De Micheli AJ, Laurilliard EJ, Heinke CL, Ravichandran H, Fraczek P, Soueid-Baumgarten S,  De Vlaminck I, Elemento O, Cosgrove BD. (2020) “Single-cell analysis of the muscle stem cell hierarchy identifies heterotypic communication signals involved in skeletal muscle regeneration.” Cell Reports 30(10): 3583-3596.E5. Link

See news report in Cornell Chronicle

17. Gheller BJ, Blum J, Soueid-Baumgarten S, Bender E, Cosgrove BD, Thalacker-Mercer A. (2019) “Isolation, culture, characterization, and differentiation human muscle progenitor cells from the skeletal muscle biopsy procedure.” Journal of Visualized Experiments 150, e59580. Link

16. Apoorva F, Loiben AM, Shah AB, Purwada A, Fontan L, Goldstein R, Kirby BJ, Melnick AM, Cosgrove BD, Singh A. (2018) “How biophysical forces regulate human B cell lymphomas.” Cell Reports 23(2): 499-511. Link

See news report in Cornell Chronicle

15. Loiben AM, Soueid-Baumgarten S, Kopyto RF, Bhattacharya D, Kim JC, Cosgrove BD. (2017) “Data-modeling identifies conflicting signaling axes governing myoblast proliferation and differentiation responses to diverse ligand stimuli.” Cellular and Molecular Bioengineering10(5): 433-450. Link

2017 CMBE Young Innovator Award Issue

14. Blau HM, Cosgrove BD*, Ho AT*. (2015) “The central role of muscle stem cells in regenerative failure with aging.” Nature Medicine 21(8): 854-862. Link

13. Sleep E*, Cosgrove BD*, McClendon MT, Preslar AT, Chen CH, Sangji MH, Pérez CMR, Haynes RD, Meade TJ, Blau HM, Stupp SI. (2017) “Injectable biomimetic liquid crystalline scaffolds enhance muscle stem cell transplantation.” Proceedings of the National Academy of Science USA 114(38): E7919-E7928. (*Equal contributions) Link

12. Porpiglia E, Samusik N, Ho ATV, Cosgrove BD, Mai T, Davis KL, Jager A, Nolan GP, Bendall SC, Fantl WJ, Blau HM. (2017) “High-resolution myogenic lineage mapping by single-cell mass cytometry.” Nature Cell Biology 19(5): 558-567. Link

11. Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn ME, Delp SL, Blau HM. (2014) Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nature Medicine 20(3): 255-264. Link

Nature Medicine | News and Views [Link]

Science | Editor’s Choice [Link]

Nature | Research Highlights [Link]

Faculty of 1000 | Recommendation [Link]

Regenerative Medicine | Research Highlights [Link]

Inside Stanford Medicine | News article [Link]

Men’s Journal | News article [Link]

10. Gardner MK, Sprague BL, Pearson CG, Cosgrove BD, Bicek AD, Bloom K, Salmon ED, Odde DJ. (2010) Model convolution: a computational approach to digital image interpretation. Cellular & Molecular Bioengineering 3(2):163-170. Link

9. Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. (2010) Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Molecular & Cellular Proteomics 9(9):1849-65. Link

8. Cosgrove BD, Alexopoulos LG, Hang T, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. (2010) Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Molecular BioSystems 6(7):1195-206. Link

7. Cosgrove BD, Sacco A, Gilbert PM, Blau HM. (2009) A home away from home: challenges and opportunities in engineering in vitro muscle satellite cell niches. Differentiation 78(2-3):185-94. Link

6. Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA.(2009) “A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes.” Conference Proceedings of the IEEE Engineering in Medicine & Biology Society 5452-5. Link

5. Lee JH, Cosgrove BD, Lauffenburger DA, Han J. (2009) “Microfluidic concentration-enhanced cellular kinase activity assay.” Journal of the American Chemical Society 131(30): 10340-1. Link

4. Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA. (2009) “Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death.” Molecular Cancer Therapeutics 8(8):2183-92. Link

3. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. (2009) “Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.” Toxicology & Applied Pharmacology 237(3)-317-30. Link

2. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. (2009) “Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.” Toxicology & Applied Pharmacology 237(3)-317-30. Link

1. Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG. (2008) “An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha.” Hepatology 48(1):276-288. Link

Book Chapters:

2. Aguilar VM, Cosgrove BD. (2017) “Microcontact-printed hydrogel microwell arrays for clonal muscle stem cell cultures.” in Methods in Molecular Biology: Skeletal Muscle Development, ed: Ryall J. Humana Press. pp. 75-92. Link

1. Cosgrove BD, Blau HM. (2010). “Skeletal muscle stem cells.” In Principles of Regenerative Medicine, 2nd edition, eds: Lanza RP, Atala A, Thomson JA, Nerem RM. Academic Press. pp. 347-363.


Key: Cosgrove Lab authors, BDC as corresponding author, * = equal contributions